One way is to edit the viewdefs located in custom\modules\MODULE\metadata. For example, if you want the Subject in Cases to be bold and red on the DetailView you'd open custom\modules\Cases\metadata\detailvewdefs.php (copy from modules\Cases\metadata if it does not exist yet) and change 'label' for 'name' to:
PHP Code:
'label' => '<strong><font color="red">{$MOD.LBL_NAME}</font></strong>',
Make sure to do a Quick Repair & Rebuild on Cases afterwards or delete DetailView.tpl from cache\modules\Cases.
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